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Objective:To explore the clinical effect of dermal and subcutaneous injection of autologous peripheral blood nucleated cells in improving periocular wrinkles.Methods:Eighteen cases of beauty seekers who planned to improve periocular wrinkles were selected as the research objects of this study. Autologous nucleated cells and blood active components were isolated and purified by negative collection mixed method and evenly injected into the periocular skin of patients. VISIA image analysis system, and satisfactory score were used to detect and evaluate the related characteristics of periocular skin at different stages before and after treatment. The scores were compared and analyzed, and the complications after treatment were recorded.Results:The 18 patients were followed up. The score of VISIA periorbital static wrinkles decreased from (22.09±8.21) before treatment to (18.31±7.84) one month after treatment, and the difference was statistically significant ( t=-7.495, P<0.05). 17 patients were satisfied; After 3 months of follow-up, 15 cases were satisfied. The texture, consistency and pore state of periorbital skin were improved in some patients (10 cases). Conclusions:Autologous peripheral blood nucleated cell therapy can improve periorbital wrinkles, especially skin fine lines, and geta high satisfactory rate. There are almost no adverse reactions after the treatment, which is worthy of clinical application.
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Objetivo: Evaluar el efecto de las células madre derivadas del tejido adiposo en el tratamiento de las arrugas periorbitarias. Métodos: Ensayo comparativo aleatorizado doble ciego en el Servicio de Cirugía Plástica del Hospital Ameijeiras, en el período comprendido entre septiembre de 2019 y julio de 2021. La muestra quedó formada por 70 pacientes que cumplieron los criterios de selección que se distribuyeron en dos grupos de tratamiento. Resultados: Predominaron las mujeres (88,6 por ciento) con promedio de edad de 47 años sin diferencias significativas entre los grupos de tratamiento. El 60,0 por ciento del grupo estudio y el 62,9 por ciento del control presentaron fototipo cutáneo II sin diferencias significativas entre los grupos (p= 0,855). El mayor porcentaje del grado de envejecimiento correspondió al III y el menor al IV (14,3 por ciento contra 20,0 por ciento), sin diferencias significativas entre los grupos (p= 0,487). Antes del tratamiento, hubo mayor frecuencia de arrugas moderadas (estudio: 42,9 por ciento; control: 51,4 por ciento) y severas (estudio: 42,9 por ciento; control: 34,3 por ciento). Posterior a la intervención, se constató una mejoría superior en el grupo estudio con cambios significativos en ambos conjuntos tratados (p< 0,001). Se presentó una complicación del grupo control (2,9 por ciento); 100 por ciento quedó satisfecho y los resultados fueron buenos en el grupo estudio (94,3 por ciento) y regulares en igual proporción del control con diferencias significativas (p< 0,001). Conclusiones: La lipotransferencia asistida con células madre ofrece resultados superiores a la convencional en el rejuvenecimiento periorbitario(AU)
Objective: To evaluate the effect of adipose tissue-derived stem cells in the treatment of periorbital wrinkles. Methods: Randomized double-blind comparative trial in the Plastic Surgery Service of the Clinical Surgical Hospital "Hermanos Ameijeiras" in the period since September/2019 until July/2021. The sample consisted of 70 patients who met the selection criteria and were distributed into two treatment groups. Results: Women predominated (88.6 percent) with an average age of 47 years with no significant differences between the treatment groups. The 60.0 percent of the study group and 62.9 percent of the control group presented skin phototype II with no significant differences between the groups (p= 0.855). The highest percentage of aging corresponded to III and the lowest to IV (14.3 percent vs. 20.0 percent), with no significant differences between the groups (p= 0.487). Before treatment, there was a higher frequency of moderate (study: 42.9 percent; control: 51.4 percent) and severe wrinkles (study: 42.9 percent; control: 34.3 percent). After the intervention, there was a superior improvement in the study group with significant changes in both treated groups (p< 0.001). There was one complication in the control group (2.9 percent). 100 percent were satisfied and the results were good in the study group (94.3 percent) and regular in equal proportion of the control with significant differences (p< 0.001). Conclusions: Stem cell-assisted lipotransfer offers superior results to conventional lipotransfer in periorbital rejuvenation(AU)
Subject(s)
Humans , Female , Middle Aged , Stem CellsABSTRACT
Objective:To evaluate the efficacy and safety of injectable compound solution of hyaluronic acid combined with botulinum toxin in the treatment of perioral wrinkles.Methods:A total of 60 female patients, aged 45-60 (53±5) years, with perioral wrinkles treated by the above mentioned method in Plastic Surgery Hospital, CAMS, PUMC from January 2018 to December 2020 were reviewed. Injectable compound solution of hyaluronic acid (2.5 ml) and botulinum toxin were injected intradermally into the upper and lower lips. Injectable compound solutions of hyaluronic acid (1.5 ml and Hearty Xiongmaozhen) were injected intradermally in the perioral static wrinkles and the lip border, respectively, as needed. The patients were followed up for 3 to 6 months after treatment. Photographs were taken before the treatment and during the follow-up visits. The pre- and post-treatment severity of perioral wrinkles were evaluated by two independent surgeons. Patients′satisfaction was evaluated.Results:All the 60 patients were included. The severity of perioral wrinkles was significantly reduced after the treatments. All the patients were satisfied with the results. Among them, 45 patients (75%) were very satisfied and 15 patients (25%) were satisfied with the results. Mild swelling occurred in all patients and was relieved in 1-5 days. Mild bruising was observed in 9 patients (15%) and was relieved in 7-10 days. No other complications were documented.Conclusions:Injectable compound solution of hyaluronic acid combined with botulinum toxin is a safe and effective method in the treatment of perioral wrinkles.
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Objective: We investigated the effects of Coix-seed Reactive Derivatives (CRD) on fibroblast proliferation and collagen production. Methods: Various concentrations of CRD (0.00001%, 0.0001%, 0.001%, 0.01%, 0.1%, 1%) were added to human fibroblasts, and changes in cell count and extracellular collagen production were measured. Results: Fibroblasts proliferated by the addition of CRD, peaked at about 1.7 times when the CRD concentration was 0.0001%, and then decreased as the addition concentration increased. On the other hand, the collagen concentration in the extracellular matrix of fibroblasts increased as the CRD addition concentration increased, and the collagen concentration increased sharply at 0.1% of CRD concentration or more. Conclusion: It was suggested that CRD has a function of increasing the proliferation of fibroblasts and collagen production.
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Las arrugas son surcos o pliegues en la piel, que aparecen principalmente por efecto del envejecimiento. Este artículo describe el caso de un paciente masculino de 47 años de edad, piel blanca, que acudió a consulta de cirugía plástica ocular por inconformidad con el aspecto envejecido de su rostro a causa de las arrugas perioculares. Se le aplicó plasma rico en plaquetas intradérmico en el trayecto de las arrugas a razón de 3 dosis con intervalo promedio de 30 días entre cada una. Se logró la corrección total de las arrugas, con buenos resultados estéticos. No se encontró reacción adversa. Se reafirma el criterio planteado por estudios de que el plasma rico en plaquetas es una opción terapéutica de primera línea para rejuvenecer la región periocular(AU)
Wrinkles are a creases or folds which appear in the skin mainly as a result of aging. A case is described of a male 47-year-old patient of white skin color who attended ocular plastic surgery consultation for dissatisfaction with the periocular wrinkles on his face, which gave it an aged appearance. Intradermal platelet-rich plasma was applied along the course of the wrinkles at three doses with an average separation of 30 days between them. Total wrinkle correction was achieved, with good esthetic results. There was not any adverse reaction. The case confirms the criterion contained in previous studies that platelet-rich plasma is a first-line therapeutic option to rejuvenate the periocular region(AU)
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Humans , Male , Middle Aged , Skin Aging , Regenerative Medicine/methods , Platelet-Rich Plasma , Mesotherapy/methods , Surgery, PlasticABSTRACT
Objective:To observe the clinical effect of booster injection of sodium hyaluronate compound solution in the treatment of neck wrinkles.Methods:From April 2020 to January 2021, Chongqing Yihengyan Medical Cosmetology Clinic recruited 50 female patients with cervical stripes, aged 32 to 56 years, with an average of 42.8 years, and divided into booster group and control group, 25 cases in each group. Patients in the booster group were injected with sodium hyaluronate composite solution to fill neck wrinkles using an automatic subcutaneous electronic syringe control booster device, while patients in the control group were injected manually with syringes. Efficacy evaluation included pain degree during injection, difficulty of injection, swelling and bruising degree after injection, complications and treatment satisfaction.Results:The pain degree ( F=0.228, P<0.01), difficulty of injection ( t=2.741, P<0.05) and the complication after injection for uneven swelling (χ 2=4.878, P<0.05), scleroma (χ 2=5.882, P<0.05), ecchymosis degree (χ 2=5.333, P<0.05) inbooster group were lower than those of control group, and the treatment satisfactory score was higher than that in control group. Conclusions:The application of booster can significantly improve the therapeutic effect of injecting sodium hyaluronate compound solution to fill the neck wrinkles, reduce complications, increase the patient＇s comfort, and ease the operation difficulty of the injector, which is worthy of clinical promotion.
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Background: Botulinum A exotoxin is an established treatment for glabellar frown lines, crow's feet, and horizontal furrows of the forehead. The glabella is probably the most common site for botulinum toxin treatment in Asians. Five glabellar contraction patterns have been classified in earlier studies based on eyebrow approximation, depression, and elevation. Unfortunately, this was found to be confusing by many practitioners. Indians, as all Asians, have smaller muscles compared to the European population, and there is no consensus on the optimal dosage per injection site or concentration of toxin to be used. Aims: (a) Identification and classification of glabellar wrinkle patterns in Indians. (b) Optimization of the minimal effective dose of toxin per site. Materials and Methods: Retrospective photographic analysis of 200 patients who received botulinum toxin for the first time to treat glabellar wrinkles was conducted. The wrinkle patterns were identified and classified by the authors based on the prevalence of perpendicular and transverse glabellar lines, nasal, and forehead wrinkles. Results: Six patterns were identified: (1) 11 (2) U (3) Pi (4) X (5) W (6) I. The relevant muscles were identified and doses optimized for those sites. Limitations: The doses mentioned in this study are not universal for all patients and toxin units would have to be altered and individualized according to the bulk of the facial muscles and individual needs. Conclusion: The investigators classification, injection patterns, and dosage may provide valuable guidance to facial esthetic treatment.
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Objective@#To introduce the SVF-gel as a filling, and the application of SVF-gel for the treatment of horizontal neck wrinkles.@*Methods@#This investigation presented a retrospective study of 30 patients (age ranged from 25 to 56 years, with mean 36 years) in Guangzhou Eye-Nose-Fat Cosmetic Plastic Clinic from December 2017 to June 2019. We used the SVF-gel injection for horizontal neck wrinkles for the patients. The effectiveness was observed 1 to 6 months later.@*Results@#No serious complications occurred in all patients. Postoperative evaluation of horizontal neck wrinkles showed that the swelling time lasted for 1-3 days, and the satisfactory rate of the doctors and patients after one month was 83.33% and 86.67%, and that after 6 months was 86.67 % and 83.33%, respectively.@*Conclusions@#SVF-gel is an effective treatment for horizontal neck wrinkles.
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Background: Aging is an inevitable biological change, but understanding the process of aging of face is important to customize the treatment options for facial rejuvenation. Evidence-based estimation of global facial aging is necessary for the validation of various treatment modalities. Aims: Classification and implementation of a scoring system for aging face based upon volume loss and surface changes as evident by drooping of different areas of the face and appearance of fine and deep wrinkles, respectively, and to apply this drooping–wrinkles classification on 54 participants to evaluate and understand the validity of scoring. Methods: An observational study was conducted, and scores were calculated based on 13 parameters (7 areas of drooping and 6 areas of wrinkles on the face) at Aura Skin Institute, Chandigarh, India. Accordingly, age was divided in different age groups followed by clinical estimation of facial age and calculation of scores. Results: According to our classification and scoring system, 61% (33 out of 54) of the participants were correlated with their chronological age group. Out of the remaining 21 (39%) participants who were aging faster, 13 (24%) were in the age group of 25–35 years. Approximately one-fourth of the patients in the age groups 36–45 and 46–55 years were aging faster. Only 1 patient had scores showing younger age in comparison to chronological age. Overall, there was a good correlation between the calculated score and the chronological age of patients. Moreover, a gradual increase in scores was noticed with increasing age groups. Conclusions: This is a new clinical classification and scoring system for facial age which is much easier to apply in daily clinical practice for easy calculation of baseline scores and customizing their antiaging treatment options. Moreover, it will also make it easier to compare the efficacy of treatment in their future follow-ups. The limitation of this study is that it has been proposed for all skin types but validation has been done only for Indian participants.
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BACKGROUND: Over the past 10 years, monopolar radiofrequency (MRF) technology has been widely used by dermatologists as a valuable modality to effectively tighten and rejuvenate photoaged skin. It also has the benefit of a short recovery time. OBJECTIVE: Using an objective parameter, this study aimed to assess the efficacy and safety of MRF, which is the basic modality of radiofrequency technologies, for treatment of periorbital wrinkles in Korean patients. METHODS: We enrolled 70 middle-aged female patients with periorbital wrinkles for this study. Each patient underwent triple sessions of MRF treatment in the periorbital region, separated by 2-week intervals. Clinical photographs were obtained, and the areas of wrinkles were measured using a Robo Skin Analyzer CS50 (Inforward Inc., Japan) at baseline and 4 weeks after the final treatment session. RESULTS: Significant reduction in the mean area of periorbital wrinkles was detected at 1-month follow-up (80.64±28.96 mm2) compared to baseline (95.08±31.93 mm2). The improvement ratio of the wrinkle area was 15.19%. Pain during procedure seemed to be tolerable without any local anesthesia for all patients. Transient mild erythema was the only side effect reported during the study. CONCLUSION: In conclusion, MRF could still be an attractive modality for Korean patients with periorbital wrinkles if the treatment is conducted repeatedly with sufficient energy and proper intervals.
Subject(s)
Female , Humans , Anesthesia, Local , Erythema , Follow-Up Studies , SkinABSTRACT
Objective To investigate the efficacy and side effects of carbon dioxide (CO2) fractional laser for the treatment of suborbital wrinkles.Methods Twenty-one female patients with suborbital wrinkles received a single treatment of CO2 fractional laser at fluences of 20-30 mJ with density of 10 ％-15 ％.Patients were photographed standardly and evaluated at baseline,one and six months after the treatment.Wrinkle improvements were graded in 5 levels:1 (no improvement or worse),2 (1％ 25％ improvement),3 (26％-50％ improvement),4 (51％-75％ improvement),and 5 (76％-100％ improvement).Patients rated the pain intensity by a visual analog scale (VAS,0 10).The side effects,such as hyperpigmentation,were observed and recorded.Results After one month follow-up,3-level improvement was observed in 7 patients (33.3％),2-level in 9 patients (42.9％);and after six months,3-level improvement was observed in 9 patients (42.9％),2-level in 8 patients (38.1％),but there was no statistically significant difference between one month and six months (P ＞0.05).The overall patient satisfactory rate was 81.0％.The average pain of VAS was 4.24± 1.73,7 patients (33.3％) had hyperpigmentation which faded within three months,and no patients had scars.Conclusions Single CO2 fractional laser treatment can improve the suborbital wrinkles in a cerrain extent with few side effects.
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Objective:To study the clinical efficacy of botulinum toxin type A injection in the treatment of upper facial dynamic wrinkles.Methods:A total of 35 patients with upper facial dynamic wrinkles treated in our hospital from February 2016 to October 2016 were selected as research objects.All the patients were treated with botulinum toxin type A.The excellence rate of 30min after treatment,3 d after treatment and 7 d after treatment were evaluated and compared.The facial wrinkles severity index of the patients were evaluated by the facial wrinkles scale (FWS),and the differences of the FWS index before treatment,4 weeks after treatment and 6 months after treatment were compared.The adverse reactions,like upper facial tension,fatigue and local injection of ecchymosis after treatment were observed and compared.Results:The excellence rate of the patients after treatment of 30 min,3 d and 7 d were gradually increased.The excellence rate of the patients after treatment of 3 d and 7 d were significantly higher than that of after treatment of 30 min,and the excellence rate of the patients after treatment of 7 d were significantly higher than that of after treatment of 3 d (P＜0.05).The FWS index of the patients after treatment of 4 weeks and 6 months were significantly lower than those of before treatment,and the FWS index of the patients after treatment of 4 weeks were significantly lower than that of 6 months after treatment(P＜0.05).After treatment,only 4 patients had slight discomfort and all of these symptoms were disappeared after 3-4 days,there was no effect on their normal work and life.Conclusion:Botulinum toxin type A injection has a remarkable clinical curative effect in the treatment of patients with upper facial dynamic wrinkles,can maintain tor a long time,and also has good safety,it is worthy clinical application.
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Objective To investigate the applicability of clinical grade and a non-contact measurement method in evaluation of underneath eye wrinkles and to compare two methods.Methods A lot of 46 healthy Chinese women were recruited for this study.Underneath eye wrinkles severity was evaluated using clinical grade and a non-contact measurement method.The correlations were calculated for clinical grade and non-contact measurement parameters and age.The non-contact measurement parameters were classified by factor analysis.The correlations between age,clinical grade and factors were analyzed.Results The correlation coefficient between clinical grade in comparison to subject's age was 0.818.The parameters getting from non contact measurement were obviously correlated with age and clinical grade except SEr and SEsc;the correlation coefficients between parameters and age were-0.601 to 0.605;the correlation cofficients between parameters and clinical grade were-0.630 to 0.570.The non-contact measurement parameters could be classified into two factors;one represented wrinkle depth and roughness;the other represented wrinkle width and counts.These two factors were also obviously correlated with age and clinical grade.Conclusions Clinical grade and non contact measurement methods are both applicable in evaluation of underneath eye wrinkles.The parameters getting from two methods are obviously correlated with each other.
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O Envelhecimento é um processo biológico dinâmico e progressivo no qual ocorrem alterações morfológicas, funcionais e bioquímicas que comprometem a manutenção da homeostasia do organismo. A redução da função das células epiteliais provoca no tecido cutâneo alterações visíveis que denunciam o envelhecimento cronológico do indivíduo com o aparecimento de linhas de expressão e rugas. O declínio na produção de colágeno e elastina são os principais responsáveis pelo aparecimento das linhas de expressão. Vários tratamentos visam aumentar a produção destas proteínas (colágeno e elastina). A técnica de micropuntura, promove indução de colágeno por meio de instrumentos que utilizam agulhas para perfurar a epiderme induzindo assim a cascata inflamatória. Este estudo teve como objetivo avaliar qualitativamente e quantitativamente os resultados da micropuntura no tratamento de rugas. A amostra foi constituída de 10 voluntárias com idade entre 30 e 45 anos com rugas na região frontal da face. As voluntárias foram submetidas a 4 sessões de micropuntura com intervalo de 7 dias. Os resultados da pesquisa validam a significância da técnica para o tratamento das rugas. (AU)
Aging is a dynamic and progressive biological process in which morphological, functional and biochemical alterations occurs which compromises organism homeostasis. The epithelial cells function reduction causes visible cutaneous tissue alterations that demonstrates the individual chronological aging through the expression lines and wrinkles. The collagen and elastin production decreasing is the main responsible for the appearance of expression lines. The treatments aim to increase the production of these proteins (collagen and elastin) by techniques such as micropuncture, which induces the production of collagen by means of instruments that use needles to pierce the epidermis and cause an inflammatory cascade. This study aimed to evaluate micropuncture results in qualitative and quantitative treatment of wrinkles. The sample was composed by 10 volunteers aged 30 to 45 with wrinkles in the frontal region of the face. The volunteers were submitted to 4 micropuncture sessions with an interval of 7 days between the sessions. The results show the technique is effective for the treatment of wrinkles.(AU)
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Humans , Female , Adult , Skin Aging , Collagen , Physical Therapy Modalities , PuncturesABSTRACT
The aim of the present study was to describe a variation of the anomalous nasi muscle in relation to the surrounding structures. The anomalous nasi muscle was found in the left face of a 40-year-old female during dissection. The anomalous nasi muscle lay on the lateral side of the nose, and it originated from the frontal process of the maxilla. The origin of the anomalous nasi muscle was located medial to the middle part of the levator labii superioris alaeque nasi muscle. It ascended superomedially to blend with the deep and lateral fibers of the superficial layer of the procerus below the level of the medial palpebral ligament. The length and width of the anomalous nasi muscle were 11.9 mm and 2.8 mm, respectively. This report demonstrated a variation of the anomalous nasi muscle, which will be helpful for understating the nasal movements and nasal wrinkles.
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Adult , Female , Humans , Ligaments , Maxilla , NoseABSTRACT
BACKGROUND: Multiple therapies involving ablative and nonablative techniques have been developed for the rejuvenation of photodamaged skin. Radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth. OBJECTIVE: To compare the efficacy of bipolar radiofrequency (Polaris™) and 1,550-nm fractional erbium-glass laser (Mosaic™) for the treatment of photoaging using a randomized, split-face, patient- and evaluator-blind study. METHODS: We evaluated the clinical effects after the treatment of photoaging. Ten Asian women (Fitzpatrick skin type III to IV) underwent 9 weeks of treatment (3 sessions at 3-week intervals) with monotherapy (Polaris™) on one side of the face and combination therapy with non-ablative bipolar radiofrequency (Polaris™) and 1,550-nm fractional erbium-glass laser (Mosaic™) on the other side. RESULTS: Among 10 patients, 4 were male and 6 were female. Subjective and objective assessments showed that the combination therapy was more effective. As the number of the treatment sessions increased, there was an accompanying increase in the satisfaction level and efficacy. CONCLUSION: This study suggests that bipolar radiofrequency combined with 1,550-nm fractional erbium-glass laser could be effective treatment for photoaging.
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Female , Humans , Male , Asian People , Clothing , Dermis , Hot Temperature , Rejuvenation , SkinABSTRACT
BACKGROUND: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. OBJECTIVE: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. METHODS: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction. RESULTS: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted. CONCLUSION: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.
Subject(s)
Compliance , Epidermal Growth Factor , Follow-Up Studies , Healthy Volunteers , Permeability , Skin , UltrasonicsABSTRACT
Se realizó un estudio casos en seis pacientes que recibieron tratamiento con láser CO2 en el Servicio de Cirugía Plástica del Hospital Vladimir Ilich Lenin, los que presentaban secuelas de acné, cicatrices hipertróficas, tatuajes, arrugas frontales, peribucales y cicatrices deprimidas, con el objetivo de evaluar su evolución y resultado estético postoperatorio. Se realizó ablación con láser CO2 modalidad continua y la profundidad se adecuo según la enfermedad y el tipo de cutis del paciente. Todos los casos evolucionaron satisfactoriamente, sin aparición de complicaciones transoperatorias o postoperatorias. El mejor resultado fue el obtenido por los pacientes con arrugas frontales y cicatrices hipertróficas, este proceder fue de utilidad en todos los casos intervenidos con mejoría estética evidente.
A case study in six patients who were treated with CO2 laser in the Plastic Surgery service of Vladimir Ilich Lenin Hospital, those with acne scars, hypertrophic scars, tattoos, facial wrinkles, perioral and depressed scars was done with the aim of assessing their progress and aesthetic surgery outcome. Continuous mode CO2 laser ablation was performed and the depth was adapted according to the disease and the patient's skin type. All cases progressed successfully without occurrence of intraoperative or postoperative complications. The best result was obtained by patients with frontal wrinkles and hypertrophic scars; this approach was useful in all cases who underwent surgery with obvious aesthetic improvement.
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Objective To assess the efficacy and adverse reactions of two cconcentrations of diluted botulinum toxin A for dynamic frontotransverse wrinkles.Methods Totally 103 cases met the inclusion criteria were assigned into two groups by a random number table:high concentration group (50 U/ml,53 cases) and low concentration group (25 U/ml,50 cases).The two groups were given the local injection with 50 U/ml and 25 U/ml concentration of botulinum toxin type A,respectively.Dosage of BTX-A,the treatment effect,the duration of the effect and the incidence of adverse reactions were analyzed.Results The high concentration group were given the BTX-A (45.53±2.05) U,the low concentration group were given the BTX-A (25.71 ± 1.74) U,and the difference were statistically significant (P＜0.05).The differences of post-operative evaluation,time of onset and duration between the two groups were not statistically significant (P＞0.05).In the high concentration group,30 cases (88.24％) had forehead heaviness sensation,and 2 cases (5.71％) in the low concentration group,the difference were statistically significant (P＜0.01).Neither of the groups was given any specific treatment,the symptoms were disappeared in two weeks.In either group there was no serious complications such as intoxication,allergy,etc.Conclusions The efficacy of local injection with two concentrations of diluted botulinum toxin A in the treatment of dynamic frontotransverse wrinkles is positive,the duration of treatment effect between the two groups is similar,and therefore the 25 U/ml concentration is recommended to reduce the forehead heaviness sensation.
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BACKGROUND: A cream made from mucus secreted by snails contains 80% mucin, as well as glycosaminoglycan, allantoin for skin rejuvenation, glycolic acid for keratin removal, and collagen and elastin, which are components of dermis. OBJECTIVE: The goal of the present study was to evaluate the efficacy of using cream containing mucus secreted by snails to reduce wrinkles, improve skin elasticity, restore dermal density, and lift the skin. METHODS: Cream containing mucus secreted by snails was applied to the lateral epicanthal areas and the left cheek of 10 subjects for 4 weeks twice per day. Wrinkles, skin elasticity, dermal density, and skin tightening were evaluated at baseline and 2 and 4 weeks. A patient survey was conducted at 4 weeks. RESULTS: There were statistically significant differences between baseline and 4 weeks after applying the cream in terms of wrinkles, skin elasticity, dermal density, and skin tightening (p<0.05). CONCLUSION: Use of cream containing mucus secreted by snails seems to be effective for anti-aging of the skin. Long term follow up studies, such as 3 or 6 months, to confirm the efficacy of the cream should be conducted involving a larger number of patients.